Trypsin
Source: Bovine (Porcine) pancreas
General description
Trypsin is a kind of serine protein hydrolase, exclusive role in composed of alkaline amino acids arginine and leucine peptide bond, soluble in **, insoluble in chloroform, ethanol, ethyl ether, and glycerin, Ca2 + is protection for trypsin and activation function.
Manufacture
Trypsin production of Beijing Geyuantianrun Bio - tech Co., ltd. is by protein chromatography technology preparation, reach the standard pharmaceutical raw materials.
Application
?As pharmaceutical raw materials manufacturing injection, infusion agent, sprays, clinical surgery used for all sorts of inflammation, ulcers, gangrene, an abscess caused by trauma, impotent, edema, hematoma and snake bites. Surgery for the treatment of tinea scabies and other skin disorders. Internal medicine for pyothorax, emphysema, bronchitis, bronchus wheeze, etc; Treatment of diabetic complications, such as nephritis; Treatment of bone disease.
?As a food processing cutting big molecular protein.
?As a proteolytic enzyme is widely applied in biology, medicine and food industries research and development, testing field.
Specification
Items Specification Standard
Appearance White or almost white lyophilized powder USP35
Solubility 500,000USP Trypsin Units is soluble in 10ml of ** and in
10ml of saline TS. USP35
Loss on drying No more than 5.0% USP35
Residue on Ignition No more than 2.5% USP35
Microbial limits：
Pseudomonas aeruginosa
Salmonella
Staphylococcus aureus Absent USP35
Chymotrypsin No more than 50 USP units/mg powder USP35
Assay Trypsin ≥ 2500USP units/mg powder USP35
Items Specification Standard
Description white crystalline powder EP6.0
Identification A) A purple color develops within 3 minutes
B) No purple color develops with in 3 minutes EP6.0
Appearance of solution Solution S is not more opalescent than reference suspension Ⅲ EP6.0
Absorbance 1) 280nm : 13.5 ~ 16.5
2) 250nm : not more than 7.0 EP6.0
PH 3.0-6.0 EP6.0
Histamine Not more than 1µg/0.2µkatal EP6.0
Loss on drying Not more than 5% EP6.0
Limit of chymotrypsin Not more than 1% EP6.0
Microbial limits
Total viable aerobic count
Salmonella
E.Coli
≤10000cfu/g
Absent
Absent EP6.0
Assay Not less than 0.5µkatal /mg, calculated on the dried basis. EP6.0
來(lái)源：豬（牛）胰腺
概述
胰糜蛋白酶是糜蛋白酶和胰蛋白酶的混合晶體，具有兩種酶的性質(zhì)。水解酪蛋白的活力與糜蛋白酶相當，水解苯甲酰酪氨酸乙酯的活力相當于糜蛋白酶的3倍，水解酯鍵的活力與胰蛋白酶相似。干燥情況下穩定，液體狀態(tài)易失活，PH7—8時(shí)活性最強。
北京格源天潤生物技術(shù)有限公司生產(chǎn)的糜胰蛋白酶是通過(guò)多重結晶方式純化，并進(jìn)一步采取超濾技術(shù)制備而得。
用途
質(zhì)量規格 1：1
|
項目 |
規格 |
執行標準 |
|
性狀 |
白色或類(lèi)白色粉末 |
企業(yè)標準 |
|
灼燒殘渣 |
不得超過(guò)2.5% |
美國藥典37版 |
|
干燥失重 |
不得超過(guò)5.0% |
美國藥典37版 |
|
效價(jià)測定 |
胰蛋白酶：1000~1100單位/毫克 糜蛋白酶 ：1000~1100 單位/毫克 |
企業(yè)標準 |
智藥研習社官方微信
制藥在線(xiàn)官方微信
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