中文名稱:泊沙康唑
中文別名:4-[4-[4-[4-[[(3R,5R)-5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-基甲基)氧雜戊環(huán)-3-基]甲氧基]苯基]哌嗪-1-基]苯基]-2-[(2S,3S)-2-羥基戊-3-基]-1,2,4-三唑-3-酮
英文名稱:Posaconazole
英文別名:2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; Sch 56592; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one; HYDROXYPROPYL]-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE; Posaconazole for research; NOXAFIL; (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
CAS:171228-49-2
分子式:C37H42F2N8O4
分子量:700.7774
熔點(diǎn):170-1720C
相對(duì)密度:1.36g/cm3
本品適用于多種對(duì)兩性霉素不能耐受或難治性成人侵襲性真菌感染的治療；對(duì)高危患者預(yù)防用藥，用于13歲以上、免疫功能低下的患者，特別是患有移植物抗宿主?。?i>graft versus host disease，GVHD）的造血干細(xì)胞移植者、白血病患者和由于化療而長(zhǎng)期白細(xì)胞減少的患者。本品比對(duì)照藥物氟康唑和伊曲康唑，能更有效預(yù)防侵襲性曲霉菌感染并可降低侵襲性真菌感染相關(guān)的病死率。
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